Difference Between Allegra and Allegra-D (with table)

An allergy is a reaction by our immune system when it’s bothered by something. People who have allergies tend to be more sensitive than people who don’t have them. Allegra and Allegra-D are the most commonly used and recommended medicines by doctors and health advisors to treat seasonal allergies.

Allegra vs Allegra-D

The main difference between Allegra and Allegra-D is that the Allegra is also known as fexofenadine, which does not contain decongestants. On the other hand, the Allegra-D is fexofenadine and pseudoephedrine which means it contains decongestants that are curable to runny noses, stuffed noses, and many others.

Allegra is also known as antihistamines. These tablets are authorized by FDA. It is developed to cure some kinds of seasonal allergies in adults and children. Skin itching and hives caused by a condition known as chronic idiopathic urticaria in adults and children can also be treated using Allegra.

Allegra-D is a combinational medicine containing fexofenadine and pseudoephedrine. These two act jointly to alleviate allergies and congestion. It relieves eight allergy symptoms with one tablet. The decongestant present in it decreases swelling of nasal passages. It’s also known as a non-drowsy antihistamine as it is less likely to fall asleep than some other histamines.

Comparison Table Between Allegra and Allegra-D

Parameters of ComparisonAllegraAllegra-D
Generic NameThe generic name of Allegra is Fexofenadine.The generic name of Allegra-D is Fexofenadine+ Pseudoephedrine.
Different FormsCan be found in Oral liquid form, Dissolving tablets, Tablets, or pills.It is generally found in pill or tablet form.
Side Effects
Side effects are headache, dizziness, nausea, drowsiness, fever, difficulty with moving, coughing.Side effects are constipation, dry mouth, skin rash or itching, feeling restless or excited, insomnia, loss of appetite.
Risk FactorsNot good for pregnant women, depression, anxiety, People with kidney problems should avoid it.Heart problem, high blood pressure, kidney problems, shortness of breath.
UsageIt is used to treat the symptoms of seasonal allergies, skin itching, and hives.It is used to treat itchy or watery eyes, skin rash, itching, stuffy or runny nose.

What is Allegra?

Allegra, which is known as fexofenadine is an antihistamine medication. It competitively alienates histamine at the H1 receptors. Allegra is used to relieving nasal and non-nasal symptoms associated with seasonal allergic rhinitis and in the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria.

Allegra can be found in many different forms such as oral liquid form, dissolving tablet, pills, or tablet form. The usual dose for adults and children over 12 years old is 180mg once daily or 60mg twice a day for allergic rhinitis, and for chronic idiopathic urticaria the usual dose is 60mg twice a day.

Do not take Allegra with Antacids containing Magnesium or Aluminium at the same time, or with grapefruit juice. It’s best to take Allegra with a full glass of water. If you miss a dose, take the missed dose as soon as you remember and if it is too close to the next dose just skin that dose and go back to your normal dosing schedule. Do not take 2 doses at the same time or an extra dose.

 Some side effects of Allegra are headache, nausea, dizziness, drowsiness, diarrhea, difficulty with moving, menstrual cramp, vomiting, upset stomach, back or muscle pain. There may be risk factors of taking this medicine if you are a pregnant woman, people with anxiety, or someone who has kidney problems so please consult with your doctor.

What is Allegra-D?

Allegra-D is an antihistamine and decongestant combination and it’s used to treat allergies that involve congestion. How it works is it blocks histamine receptors that cause this runny nose allergy symptoms also with the decongestant it opens up your sinuses and opens up blood vessels. The generic name of Allegra-D is Fexofenadine+ pseudoephedrine. It is found in pill and tablet form.

You take the Allegra-D twice a day. If you happen to forget and miss your dose and if it is closer to the next dose just go ahead and skip it and if not go ahead and take it. But you should not take two doses at the same time. Allegra-d should be taken on an empty stomach with a full glass of water. Store the Allegra-D in a cool dry place. Cloths’ closet is good place to keep medication.

Some side effects of using Allegra-D are headache, insomnia with the Sudafed portion the decongestant, constipation, dry mouth, loss of appetite. Risk factors of using it are heart problems, high blood pressure, kidney problems, shortness of breath.

Main Differences Between Allegra and Allegra-D

  1.  Allegra relieves the allergy symptoms like skin itching and chronic hive without making you feel sleepy, whereas Allegra-D is an allergy medicine that is used when you have a runny nose and nasal congestion.
  2. Allegra can be found in many different forms such as oral liquid form, dissolving tablet, pills, or tablets form, on the other hand, Allegra-D can be found only in pills and tablets.
  3. The generic name of Allegra is Fexofenadine, whereas the generic name of Allegra-D is Fexofenadine+Pseudoepherdrine.
  4. The risk factors of using Allegra are when it’s used in the excess amount it causes brain damage because of the excess amount of phenylalanine, whereas the risks of using Allegra-D are heart problems, shortness of breath, driving impatience, seizures.
  5. The pricing of Allegra is cheap and it’s easily available in medical stores, on the other hand, Allegra-D is pricier than the medicine Allegra.


Allegra and Allegra-D are the most common medicine for the treatment of seasonal allergies, for the relief of nasal or non-nasal symptoms. Allegra relieves symptoms like skin itching, chronic hive without making the person feel sleepy whereas Allegra-D is used when someone has a runny nose and nasal congestion. Both of the medicine should be taken twice a day directed by your doctor or health advisor.


  1. https://link.springer.com/article/10.1007/BF02725339
  2. https://link.springer.com/article/10.1245/ASO.2003.03.018