Difference Between Adrenaline and Epinephrine (With Table)

Although they are two different names for the same hormone, adrenaline and Epinephrine are interchangeable. Such terms usually do not have the same meaning; however, this is not the case with this particular pair of words. Adrenaline and Epinephrine are two names for the same hormone; in most circumstances, you will observe that they have slightly distinct effects.

Adrenaline and Epinephrine are used as medicines in treating shock, anaphylactic allergic reactions, cardiac arrest, and other medical conditions. Even though they seem identical, both medications raise blood pressure when administered. However, their roles in the body are somewhat distinct. It will be explained in this article what the differences are between Adrenaline and Epinephrine:

Adrenaline vs Epinephrine

The main difference between adrenaline and Epinephrine is that adrenaline is the name approved by the United Kingdom. Also known as “Epinephrine,” the hormone generated by the adrenal gland medulla is called “Epinephrine” by the international community. On the other hand, even though adrenaline and Epinephrine are implicated in the fight-or-flight reflex, they serve unique functions in the body, releasing adrenaline in response to a stressful or thrilling circumstance. In contrast, Epinephrine is released in response to stress.

When a foreign object, such as a bee sting or a dog bite, attacks the body, adrenaline is released. It is in charge of getting your body ready for war by boosting your heart rate and tightening your muscles so that you will be prepared to fight.

The chemical name epinephrine knows adrenaline. It is a hormone generated by the adrenal glands to assist the body in responding to stress and dealing with potentially dangerous or detrimental conditions. This can be the case. You may experience nausea, dizziness, a rapid heartbeat and low blood pressure if your Epinephrine levels rise due to being anxious or upset.

Comparison Table Between Adrenaline and Epinephrine

Parameters of ComparisonAdrenalineEpinephrine
TypeSuppresses the body’s responsiveness to external stimuli.    As a sympathomimetic drug, Epipen works by stimulating the sympathetic nervous system.
Another nameAmong other names for adrenaline, you could hear the term “epinephrine” or “epinephrine rush.”Other names for Epinephrine are adrenaline and norepinephrine.
ResponseAdrenaline, a neurotransmitter inside the brain, regulates the heartbeat, blood pressure, & respiration of a body’s occupants.Epinephrine is a chemical released in response to stress, terror, and other emotional states.
StructureIt is derived from phenylalanine, which is the building block of adrenaline.Tyrosine serves as a building block for epinephrine production.
ReceptorsWhen you take adrenaline, you stimulate the release of adrenergic receptors from numerous subgroups (adrenergic receptor subtypes 1–2, 1–2, 3), as well as several subtypes of the adrenergic receptor subtype 2A–2C.Adenosine triphosphate binds to both adrenergic receptor subtypes: beta and alpha.
PropertiesIt is believed that adrenaline offers you more energy because it activates your neurological system, boosts your heart rate, and opens up your airways, making it easier for you to breathe.Also known as adrenaline, this hormone dilates blood vessels and increases the production of glucose (sugar) by the liver, which increases overall energy levels.
Founded byHeinrich Drysdale Dakin and Friedrich Stolz both formed their own company, Adrenaline, in the year 1904.German chemist Friedrich Stolz discovered Epinephrine in 1904 and published his findings in 1905.

What is Adrenaline?

Probably the first thing that comes to mind when you hear the word adrenaline is something exhilarating, like a roller coaster ride or a life-threatening event. Adrenaline therapy for the treatment of cardiac disease is not a new concept. It has been used to treat specific types of anaphylaxis for many years now (severe allergic reactions).

Chronic heart failure, where the heart cannot pump enough blood to meet the body’s needs, and cardiac arrest are also routinely treated with adrenaline (when the heart suddenly stops beating).In these situations, adrenaline assists the heart in continuing to pump until further treatments can be used.

People who have congenital cardiac abnormalities, which cause blood to flow more slowly through their bodies, may also benefit from the administration of adrenaline on occasion. In certain instances, adrenaline forces blood arteries known as veins to constrict, resulting in increased pressure in the veins around the heart and the forced return of more blood to it. In extreme situations that would typically necessitate surgery, this treatment can help to slow or even temporarily stop the bleeding.

What is Epinephrine?

Known as the “fight or flight” hormone, Epinephrine is produced by the body in response to stress. These unnoticed bodily functions are controlled by the adrenal glands’ release of this hormone, part of the body’s autonomic nervous system. Throughout a person’s life, their bodies will manufacture modest levels of Epinephrine. EpiPens are used to treat people who have severe allergic reactions.

When the medicine binds to specific receptors in the body known as alpha-1 receptors, it begins to operate. When this occurs, some molecules in the body become more active, which can aid in the restoration of normal blood pressure and other bodily functions. In addition, the medication relaxes the muscles in the lungs, which helps to prevent respiratory failure in severe cases. Epinephrine can also be administered intravenously or by injection into a muscle, depending on the situation.

You or someone close to you has likely had an allergic response in the recent past. Symptoms of these responses include itchiness, hives, and swelling, which can progress to trouble breathing and shock. Foods that cause these reactions are commonly found in shellfish, almonds, and berries.

Main Difference Between Adrenaline and Epinephrine

  1. Adrenaline and Epinephrine are used to treat cardiac arrest and hypotension (low blood pressure).
  2. The hormone adrenaline helps your body deal with stress & dangerous or harmful events, while Epinephrine can be helpful if you need to fight or run away from something and have more energy. If you don’t control it, it can hurt your health.
  3. On the other hand, adrenaline comprises a distinct set of amino acids than Epinephrine. Phenylalanine is the building block for adrenaline, while tyrosine is the building block for Epinephrine.
  4. Adrenaline, unlike Epinephrine, does not include sulfur; hence it has distinct chemical features. On the other hand, sulfur, carbon, & hydrogen make up the epinephrine molecule’s structure.
  5. The adrenaline hormone is secreted into the bloodstream in times of danger or stress. Unlike adrenaline, which is synthesized by the adrenal glands, Epinephrine is synthesized by the body.


Adrenaline and Epinephrine are the two most important hormones when keeping the body healthy. Any time an occurrence occurs before, during, or after trauma, it’s most likely the result of adrenaline, and Epinephrine is more likely to cause a subsequent, non-traumatic event.

Their imbalance can cause various health problems even though they conduct many activities. In addition, these two hormones are so similar that it may be difficult for you to tell them apart during your investigation.


  1. https://www.sciencedirect.com/science/article/pii/S0300957211006423
  2. https://www.bmj.com/content/327/7427/1332?tab=responses&ld=20140101&ap=3&app=1&c=uk.dogpl&s=dogpileuk&coi=239138&cop=main-title&euip=