Difference Between Acetone and Chloroform (With Table)

Science and technology are extremely important in today’s environment. Various materials are required for discoveries and technological implementation.Chemicals are required for any type of invention. Individuals use them for nearly every task in their everyday lives. We’ve shown a differentiator between Acetone and Chloroform in this article.

Acetone vs Chloroform

The main difference between Acetone and Chloroform is that Acetone (propanone or dimethyl ketone) is a colourless, volatile, highly combustible chemical molecule with a distinctive odour, on the other hand, Chloroform (trichloromethane) is a colourless, thick, sweet-smelling chemical substance.

Acetone is primarily used as a solvent for cleaning equipment, thinning polyester resin, and thinning paints and varnishes. It’s a cleanser that’s used to clean metal before coating it. Acetone is a chemical that is utilised in cosmetic and pharmaceutical products as well as food ingredients. It is employed as an excipient in some medications and as a denaturant in denatured alcohol in the pharmaceutical sector. Acetone is a solvent that is used to store and transfer acetylene safely. It’s utilised in the production of methyl methacrylate.

In chromatography and spectroscopy, chloroform is extensively employed. It was once commonly used as an anesthetic. Chlorodifluoromethane was common refrigeration before the Montreal Protocol for ozone depletion protection. Chloroform degrades lipids well and can cause sores if it is applied to the skin. Chloroform affects the central nervous system, inducing coma and respiratory distress when consumed or breathed.

Comparison table between Acetone and Chloroform

Parameters of comparisonAcetoneChloroform
DefineAn organic chemical that is volatile, highly flammable, and has a characteristic odour. A liquid that is made up of organic compounds and is colourless, thick, and sweet-smelling.
EffectsIt ends up causing slight discomfort when it comes into contact with the skin, and it irritates the eyes and respiratory system when swallowed. When used in excess, it is extremely poisonous. It can cause jaundice or even coma.
ImportanceIn industry, Acetone is used as a solvent. Acetone is used as a paint stripper in the home and can eliminate paint and nail polish marks. In the medical field, Chloroform is used as a solvent and as a sedative. It’s also utilised in fire extinguishers and as refrigeration.
FlammableIt’s less poisonous and extremely flammable.Non-flammable and highly poisonous.

What is Acetone?

Andreas Libavius synthesised acetone, also known as propanone or dimethyl ketone, for the first time by pyrolyzing lead acetate. Acetone is secreted in minute amounts in our bodies, but it is plentiful in others, such as people with diabetic ketoacidosis, an existing diabetic illness. Individuals who fast for lengthy periods and follow a low-carb meal have a high concentration of the Ketone group of acetones in their bodies.

During World War I, acetone was manufactured using a fermentation technique involving Clostridium acetobutylicum bacteria. Ketosis happens when the body’s ketones are elevated.

Acetone is formed as a result of this procedure. Acetone can also be used to treat skin conditions because it is a chemical exfoliant. It’s employed in the exfoliating process’s tries to eliminate steps. Because of its high volatile nature, acetone has fewer ecological impacts.

Apart from these uses, acetone is also utilised as a reagent in many laboratory investigations. Acetone is secreted in minute amounts in our bodies, but it is plentiful in others, such as people with diabetic ketoacidosis, a life-threatening diabetic illness.

What is Chloroform?

Chloroform, one of the most common anaesthetics, is manufactured for industrial applications for use in pharmacies. Some types of fungus and seaweeds also generate it. It is a volatile substance that does not build up in aquatic creatures. Its flammability allows it to escape the soil and disintegrate into the atmosphere.

Chloroform is an organic solvent that was discovered in the early nineteenth century by two distinct scientists, one from the United States and the other is from France. Medical practitioners have stopped using Chloroform as anaesthesia due to its hazards. As a result, its application in medicine is restricted.

Natural sources emit 90 percent of the chloro in the atmosphere. The generation of chloroform is caused by both abiotic and biotic causes. When the whitening powder is used with ethyl alcohol to sanitise ordinary household items, a little amount of chloroform is produced. For NMR spectroscopy, chloroform is employed as a solvent.

In the 1850s, chloroform was utilised for surgical management in the United Kingdom. Chloroform causes cardiac fibrillation, which was experimentally proven in 1911. Criminals also use it unlawfully to take out their victims. It is typically detected in chlorinated tap water because it is generated when bleaching powder reacts with other substances.

Main Difference between Acetone and Chloroform

  1. Acetone vapour intake causes drunkenness and dizziness whereas Chloroform affects the central nervous system, inducing coma and respiratory distress when consumed or breathed.
  2. Acetone has the chemical formula C3H6O whereas chloroform has the chemical formula CHCl3.
  3. Acetone is widely used as a solvent, degreaser, and in cosmetic and pharmaceutical applications, as well as in food products. It’s a common ingredient in cleansers and nail polish removers whereas Chloroform is being used to make polytetrafluoroethylene and tetrafluoroethylene, as well as in insecticides, resin, rubber, oils, fats, gutta-percha, waxes, alkaloids, chromatography, and spectroscopy.
  4. Alchemists were among the first to synthesize acetone in the medieval Era whereas, In 1831, many investigations carried synthesised chloroform.
  5. Acetone is manufactured in industrial, either explicitly or implicitly, from propylene. At extreme temps chloroform is made from methane or chloromethane and chlorine.


Acetone and chloroform are two chemical compounds that are not the same. They have different qualities and consequently different roles. Acetone will never be able to take the place of chloroform, and vice – versa. Acetone, which was identified before Chloroform, is just as important as the latter. Chemicals are quite useful, but they often have a negative side. They have deadly or moderate effects on people if used more than a particular level. As a result, it’s often preferable to use caution when handling chemicals.


  1. https://www.google.com/url?sa=t&source=web&rct=j&url=https://en.m.wikipedia.org/wiki/Acetone&ved=2ahUKEwjrttaQtan2AhULSmwGHYgoCfYQFnoECAUQAQ&usg=AOvVaw0m539sgKqo4AX5JwnEY_jF
  2. https://www.google.com/url?sa=t&source=web&rct=j&url=https://en.m.wikipedia.org/wiki/Chloroform&ved=2ahUKEwjblNustan2AhUTjuYKHb3wBsgQFnoECAUQAQ&usg=AOvVaw0tlG7GnNQcp2xpviT2PONk