Difference Between 5 Dextrose And Dextrose Saline (With Table)

With pharmaceuticals coming to the limelight more often than not we have many factors that run the Pharma industry. 5 Dextrose and Dextrose saline are the two components of it.

Dextrose, in particular, is known as an intravenous fluid that is only used for intravenous purposes meaning going into the vein directly. It is a type of glucose mixed with water.

It is available in different strengths varying from 100ml to 1000ml.

5 Dextrose vs Dextrose Saline

The main difference between 5 Dextrose and Dextrose saline is that 5 Dextrose is isotonic but later turns to hypotonic whereas Dextrose saline is hypertonic in nature.

5 Dextrose is a mixture of dextrose and water where 5 resemble the percent of dextrose that is present in the water. 5 denotes the percent of dextrose present in 100 ml of water. 5 Dextrose does not contain Sodium Chloride and is chemically different from other variants. It is used in times of Cellular Dehydration, dilute drugs, etc.

Dextrose saline being hypertonic in nature and having the highest pressure to pass through a semi-permeable membrane makes it irrelevant from 5 Dextrose. The percent of Sodium Chloride in this mixture depends on its usage. It is used as a sterile saline solution for entering the body for intravenous administration.

Comparison Table Between 5 Dextrose and Dextrose Saline

Parameters of Comparison5 DextroseDextrose Saline
CompositionComposed of 5gms of a dextrorotatory form of glucose and waterComposed of a dextrorotatory form of glucose, Sodium Chloride, and Water
NatureIsotonic in the bottle but Hypotonic when in bodyHypertonic in nature
Type of FluidNot Parental FluidParental Fluid
MovementThe solvent is water, have aqueous solution movementExhibits highest pressure to pass through a semi-permeable membrane
UsesMaintaining water balance when eating is not an optionReplace Water losses post-surgery in conjunction with salt retaining fluid i.e. saline

What is 5 Dextrose?

5 Dextrose is a mixture of dextrose and water. It is an intravenous sugar solution that is composed of 5gms of a dextrorotatory form of glucose dissolved in 100gms of water. It is isotonic initially but when it reaches the blood vessel, turns hypotonic as dextrose gets utilized by the body entering the cells. The rest water enters cells causing cellular swelling and hence is not preferable post-surgery.

It is solvent in water and its aqueous solution movement helps in the movement of water coming out from the cell which is balanced by the movement of water into the cell thus forming an isotonic solution. It can be used for the following purposes:

  1. Cellular dehydration- The ability to pierce into cells makes it very effective in terms of cellular dehydration.
  2. Providing Calories- Very effective in providing calories when the subject can’t intake any food or energy from own.
  3. Ketosis Reaction- It’s very reactive when gets in blood vessel and process ketosis which prevents from starvation.

5 Dextrose is also not suitable for the following purposes:

  1. When undergoing neurosurgery
  2. In case of Acute Ischemic Stroke
  3. In case of water intoxication
  4. In case of Hypovolemic shock    

What is Dextrose Saline?

Dextrose saline is a mixture of 5 percent dextrorotatory form of glucose, Sodium Chloride, and water. It contains Sodium and Chloride ions and the quantity varies on usage. It is a sterile saline solution that enters the body’s veins also known as intravenous administration. It is also called parental fluid because helps in electrolyte nourishment after entering the body through veins.  They exhibit the highest pressure to pass through semi-permeable membranes and are Hypertonic in nature.

Dextrose saline helps in electrolyte nourishment of the body so it is helpful in the usage of post-surgery in replacing water losses in conjunction with salt retaining fluid. The Sodium Chloride that is present here is combined together in the form of Na+ ions and Cl ions.

Dextrose saline can be used for Diabetic patients, patients with breathing problems have a high percentage of sodium chloride so can be used in pregnant women post-surgery that does helps in cellular recovery, and prevents dehydration. It comes with no side effects but rarely skin rashes, red spots or itchy skin can be seen.

Main Differences Between 5 Dextrose and Dextrose Saline

  1. 5 Dextrose and Dextrose saline is different and irrelevant from one other hence is used in very different situations. 5 Dextrose being hypotonic is water soluble and isotonic in bottle. It is a type of glucose that goes into the vein directly and is available in different strengths. While Dextrose saline is a mixture of 5 percent dextrorotatory form of glucose, Sodium Chloride and water. The quantity of Sodium chloride varies according to the usage.
  2. 5 Dextrose is generally isotonic but when enters into the vein it becomes hypotonic thus causing cell swelling. Dextrose saline on the other hand is hypertonic in nature and thus helps in cell dehydration and post surgery.
  3. The nature of 5 Dextrose is not parental but Dextrose Saline is parental in nature because of helping in electrolyte nourishment.
  4. The 5 Dextrose is soluble in water and have aqueous solution movement and can penetrate easily. The Dextrose saline exhibits high pressure to pass through semi permeable membrane
  5. The main use of 5 dextrose is to maintain the water balance in the body when eating is not an option while Dextrose saline can be used to pregnant women after surgery for recovery.

Conclusion

Both the 5 Dextrose and Dextrose saline helps in building and maintaining the proper body activity of a person. The composition of both the products is different but dextrose is present in both which is a common factor between the two.

Both being a pioneer in each field has their very own quality and specifications that do make them the active usable products in the pharmaceutical field.

References

  1. https://www.sciencedirect.com/science/article/pii/S0140673682922279
  2. https://journals.lww.com/greenjournal/fulltext/2013/02000/Dextrose_Saline_Compared_With_Normal_Saline.13.aspx